ZIA CP010133-10030 (ZIA) | |||
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Title | Fluorescence in situ Hybridization (FISH) Chromosomal Aberration Analysis among US Radiologic Techno | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Sigurdson, Alice | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $344,261 | Project Dates | 07/01/2003 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Radiation - Ionizing - Total (100.0%) Radiation - Ionizing Low Level (100.0%) |
N/A | ||
Research Type | |||
Normal Functioning Exogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
The National Cancer Institute (NCI) in collaboration with the National Institute for Occupational Safety and Health (NIOSH) is conducting a study to determine the relationship between occupational radiation exposure and the frequency of chromosomal aberrations (measured by Fluorescence in situ Hybridization or FISH) in the peripheral blood lymphocytes of a group of radiologic technologists estimated to have low, moderate, and high cumulative radiation exposure based on reconstructed doses from work histories and some limited badge dose measurements. A comparison group of radiologic technologists estimated to have extremely low cumulative exposure will also be selected who were eligible (certified) to work, but worked either few years or not at all. The time period of greatest interest is prior to 1950, a time when occupational radiation doses were the highest. Thus, we plan to conduct a biodosimetry study using FISH to examine the relationship between our estimated radiation doses and stable chromosome aberration frequency in the peripheral blood lymphocytes of 150 radiologic technologists who are still living and were eligible to work before 1950. |